3D Cell Culture: Revolutionizing Laboratory Models

3D cell culture is changing how scientists do research in labs. Instead of growing cells flat on dishes, 3D culture lets cells grow in all directions, just like they do in our bodies. This helps researchers learn more about how cells really work and interact. It’s especially useful for studying diseases and testing new medicines. Let’s explore how 3D cell culture is making a big difference, focusing on two important types of cells: HepG2 liver cells and SH-SY5Y brain cells.

Key Points: 3D Cell Culture

• More accurately mimics real tissue environments compared to 2D cultures
• Enables better modeling of diseases and drug responses
• HepG2 liver cells and SH-SY5Y brain cells are crucial for 3D research
• Allows for more complex experiments and improved understanding of organ systems
• Contributes to development of better treatments and personalised medicine
• UK companies like Cytion offer high-quality, 3D-optimised cell lines for scientists

In this article, we’ll look at how 3D cell culture works and why it’s so important. We’ll focus on HepG2 and SH-SY5Y cells, which help scientists study liver and brain diseases. These cells are like tiny models of real organs, letting researchers test new ideas and medicines in ways that weren’t possible before.

What is 3D Cell Culture?

3D cell culture is a way of growing cells in the lab that’s much more like how they grow in our bodies. Instead of growing flat on a dish, cells in 3D culture can grow in all directions. This makes little clumps of cells that look and act more like real tissues. In 3D culture, cells can talk to each other and stick together just like they do in our organs. This helps scientists see how cells really behave and react to things like medicines.

Researchers use 3D cell culture to study all sorts of things, like cancer, how to grow new organs, and how safe new medicines are. It’s a big step forward from the old way of growing cells flat on dishes.

HepG2 Cells in 3D Models

HepG2 cells come from human liver cancer, but they’re really useful for studying how the liver works. In 3D culture, these cells form groups that look a lot like tiny pieces of real liver. This helps scientists test new medicines to see if they might hurt the liver, study liver diseases, and even try to grow new liver tissue.

Here’s what scientists can do with 3D HepG2 cultures:

• Test if new medicines might damage the liver
• Study liver diseases like fatty liver disease
• See how the liver breaks down medicines
• Try to grow new liver tissue for transplants

HepG2 cells in 3D culture act more like real liver cells. They make more of the proteins that real liver cells make and are better at showing how the liver might react to medicines. This helps scientists make safer, more effective treatments.

SH-SY5Y Cells and Brain Research in 3D

Learn about the latest developments in 3D #cellculture #imaging from three experts coming from academia, biotech, and pharma. In this upcoming webinar on March 13, learn about:

• Challenges and opportunities associated with imaging of 3D cell culture models

• Insights on how… pic.twitter.com/NosqCMlqnU

— ZEISS Microscopy (@zeiss_micro) March 6, 2024

SH-SY5Y cells are special cells that scientists use to study the brain. In 3D culture, these cells grow little branches like real brain cells do. This makes them great for learning about how the brain works and what goes wrong in brain diseases.

Scientists use 3D SH-SY5Y cultures to:

• Study brain diseases like Alzheimer’s and Parkinson’s
• Test new medicines that might protect brain cells
• Learn how brain cells grow and change
• See if chemicals might hurt brain cells

3D cultures of SH-SY5Y cells show how brain cells connect and work together. This helps scientists understand brain diseases better and come up with new ways to treat them. For example, researchers have used these 3D cultures to study how clumps of proteins form in Alzheimer’s disease, which is hard to do with flat cell cultures.

Why 3D Cell Culture is Great for Finding New Medicines

3D cell culture is changing how scientists find new medicines. It’s better than old methods because it’s more like real human bodies. This means scientists can test new medicines more accurately before trying them in people. Here’s why 3D cell culture is so good for medicine research:

• It shows how medicines might work in the body more accurately
• It reduces the need for testing on animals
• Scientists can study how medicines work over long periods
• It helps create personalized medicines for individual patients
• It’s better for studying complex diseases like cancer

Both HepG2 and SH-SY5Y cells in 3D cultures are helping scientists find new medicines faster and more reliably. HepG2 cells help test if medicines might hurt the liver, while SH-SY5Y cells help test medicines for brain diseases. This means scientists can find good medicines more quickly and be more confident they’ll work in people.

Cytion: Helping Scientists with 3D Cell Culture

Cytion is a company that helps scientists do 3D cell culture research. They provide high-quality HepG2 and SH-SY5Y cells that are specially prepared for 3D culture. Cytion doesn’t just sell cells; they offer complete solutions to help scientists get the most out of 3D cell culture.

Here’s how Cytion helps researchers:

• They provide cells that are tested to work well in 3D cultures
• They offer special food and supplements for 3D cell cultures
• They give scientists instructions and help on how to do 3D cell culture
• They can create custom solutions for specific research projects

By working with Cytion, scientists can do their research faster and better. Cytion’s knowledge about cells and 3D culture helps researchers try new things and make important discoveries in medical science.

Conclusion

3D cell culture is a big step forward in how scientists study the human body and diseases. It lets researchers see how cells behave in ways that are much more like real life. This is helping them understand diseases better and find new treatments faster.

HepG2 and SH-SY5Y cells grown in 3D are especially useful for studying the liver and brain. These cell cultures are helping scientists learn things they couldn’t before, which could lead to new medicines and treatments.

Companies like Cytion are important because they provide the tools scientists need to do this advanced research. As we keep learning more about how our bodies work and what causes diseases, 3D cell culture will play a big role in making new discoveries and developing better treatments to help people stay healthy.

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